Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales. Information is stored in sequences, epigenetic modifications, and rapidly changing nucleoprotein complexes. Because DNA must operate through complexes formed with other molecules in the cell, genome functions are inherently interactive and involve two-way communication with various cellular compartments. Both coding sequences and repetitive sequences contribute to the hierarchical systemic organization of the genome. By virtue of nucleoprotein complexes, (...) epigenetic modifications, and natural genetic engineering activities, the genome can serve as a read-write storage system. An interactive informatic conceptualization of the genome allows us to understand the functional importance of DNA that does not code for protein or RNA structure, clarifies the essential multidirectional and systemic nature of genomic information transfer, and emphasizes the need to investigate how cellular computation operates in reproduction and evolution. (shrink)

Since its introduction in 1987, Benjamin Freedman’s principle of clinical equipoise has enjoyed widespread uptake in bioethics discourse. Recent years, however, have witnessed a growing consensus that the principle is fundamentally flawed. One of the most vocal critics has undoubtedly been Franklin Miller. In a 2008 paper, Steven Joffe and Miller build on this critical work, offering a new conception of clinical research ethics based on science, taking what they call a “scientific orientation” toward the ethics of clinical research. Though (...) there is much to recommend Joffe and Miller’s scientifically oriented conception of clinical research ethics, I believe that both the critical and constructive projects suffer from the same basic mistake: inattention to context. The internal norms of science cannot be fully specified, let alone satisfied, independently of contextual (external) factors that only come into view when we are attentive to the particular context of that form of inquiry. (shrink)

Intentionalism is the view that statutes should be interpreted in accordance with the intentions of the legislatures that produce them. As a theory of legislative interpretation, intentionalism has been very influential, but it has also been subject to much critical attention. It is claimed that legislatures will seldom have any relevant intentions, and that even if they did, we could not come to know them. I propose a modification of intentionalism that significantly mitigates the severity of these problems. I begin (...) by noting that legislation is seldom (if ever) written by an entire legislature. Instead, it is commonly written by individuals or subgroups acting as proxies on behalf of the legislature. I then argue that the reasons why legislation should be interpreted in accordance with the intentions of legislatures are equally applicable to the intentions of proxies. This is significant because proxies are much more likely to have ascertainable intentions. (shrink)

. This paper questions nearly every major point Christina Lafont makes about “the validity of social norms” and their relation to moral realism and Kantian constructivism. I distinguish realisms from theories of objective or subjective knowledge, then from cognitivism. Next, I distinguish Kant and constructivism from Rawls' political constructivism. Finally, I propose clues for an alternative theory of moral constructivism.

In this paper, we set out what we see as a novel, and very promising, approach to resolving a number of the familiar linguistic puzzles that provide philosophy of language with much of its subject matter. The approach we promote postulates semantic pretense at work where these puzzles arise. We begin by briefly cataloging the relevant dilemmas. Then, after introducing the pretense approach, we indicate how it promises to handle these putatively intractable problems. We then consider a number of objections (...) to pretense views, taking this as an opportunity to provide more detailed explanation of what a pretense account amounts to, what the pretense approach commits us to, and why it is a promising approach in philosophy of language. (shrink)

In this paper we explain our pretense account of truth-talk and apply it in a diagnosis and treatment of the Liar Paradox. We begin by assuming that some form of deflationism is the correct approach to the topic of truth. We then briefly motivate the idea that all T-deflationists should endorse a fictionalist view of truth-talk, and, after distinguishing pretense-involving fictionalism (PIF) from error- theoretic fictionalism (ETF), explain the merits of the former over the latter. After presenting the basic framework (...) of our PIF account of truth-talk, we demonstrate a few advantages it offers over T-deflationist accounts that do not explicitly acknowledge pretense at work in the discourse. In turning to the Liar Paradox, we explain how the quasi-anaphoric functioning that our account attributes to truth-talk provides a diagnosis of the Liar Paradox (and other instances of semantic pathology) as having no content—in the sense of not specifying any of what we call M-conditions. At the same time, however, we vindicate the intuition that we can understand liar sentences, thereby avoiding one standard objection to “meaningless strategy” responses to the Liar Paradox. With this diagnosis in place, we then, by way of treatment, introduce a new predicate, ‘semantically defective’, and show how the explanation we give for its application allows for a consistent, yet revenge-immune, (dis)solution of the Liar Paradox, and semantic pathology generally. (shrink)

Why do bad things happen, even to good people? If there is a God, why aren't God's existence and God's will for humans more apparent? And if God really does miracles for some people, why not for others? This book examines these three problems of evil - suffering, divine hiddenness, and unfairness if miracles happen as believers claim - to explore how different ideas of God's power relate to the problem of evil.

This article explores the idea that Core Affect provides the emotional quality to any conscious state. Core Affect is the neurophysiological state always accessible as simply feeling good or bad, energized or enervated, even if it is not always the focus of attention. Core Affect, alone or more typically combined with other psychological processes, is found in the experiences of feeling, mood and emotion, including the subjective experiences of fear, anger and other so-called basic emotions which are commonly thought to (...) be raw, primitive, and universal. (shrink)

Psychology, philosophy and common sense -- Psychological empiricism (part A): do non-empirical psychological phenomena exist? -- Psychological empiricism (part B): a critique -- The subject matter of psychology (part A): the conscious personal self -- The subject matter of psychology (part B): differing kinds of psychic phenomena -- Locating the empirical in psychology -- Human nature and rational psychology -- Psychology, truth and personalism -- The reality and psychological significance of freedom.

The eighteenth century was a time of brilliant philosophical innovation in Britain. In Of Liberty and Necessity James A. Harris presents the first comprehensive account of the period's discussion of what remains a central problem of philosophy, the question of the freedom of the will. He offers new interpretations of contributions to the free will debate made by canonical figures such as Locke, Hume, Edwards, and Reid, and also discusses in detail the arguments of some less familiar writers. Harris (...) puts the eighteenth-century debate about the will and its freedom in the context of the period's concern with applying what Hume calls the "experimental method of reasoning" to the human mind. His book will be of substantial interest to historians of philosophy and anyone concerned with the free will problem. (shrink)

This dissertation does not argue for a particular theory of realism. It seeks to clear the ground for such a theory by clarifying the distinction between realism and reality. Realism is not reality. 'Realism' stands for theories that describe reality and how it exists mind-independently. I argue that much recent writing on realism misses the import of this distinction and proceeds "anti-philosophically." While some statements refer uncontroversially to an accepted state of affairs, others amplify, vouchsafe, or explain a philosophical compunction (...) about the received notion of reality. Philosophy consists, in accounting for what one does, says exists, or knows. So, the mere acceptance of the supposed "facts" is anti-philosophical. ;Philosophy should accept at least some "facts." But it has to rise above first order obviousness in order to dismiss or accept received views. The effort to proceed "antiphilosophically," insists that some statements or material be accepted uncritically or neutrally as explaining or settling important philosophical issues without philosophical assistance. ;Accordingly, I reject Devitt's "proposal" that we can "settle the realism issue before any epistemic or semantic issue" . Issues of reference cant help but pertain to settling that "Tokens of most current common-sense and scientific objects objectively exist independently of the mental" . The "constructivist turn" in realism holds that "realism" describes mind-independent entities, but not in a way that is itself independent of knowledge or meaning. Realism and much else, including our "facts," is "constructed" ; reality isn't. Hence, I also reject John Searle's attempt to "construct" all of social reality from non-social or "brute" reality alone. It is only by the social that we know the "non-social." I reject Michael Dummett's theory that the theory of meaning "underlies" metaphysics. Regardless, statements still refer to entities, without which they mean nothing. I favor Hilary Putnam's attempt to reject metaphysical realism despite his leanings toward idealism and a "limit concept" of reason and truth. Finally, I argue that Rorty's arguments for the "pointlessness" of realist and antirealist discussion are self-contradictory and nearly irrelevant. (shrink)

Seeing objective thought as passive, Diefenbeck seeks to develop a theory of thought or of reason “appropriate to the subject as an active agent or first cause.” His system would illuminate and render more effective the creation of values that guide lives. George Kimball Plochmann in his foreword describes the book as “a sus­tained inquiry into the character of knowledge, one seeking to prove that our exclusive cognitive allegiance to the so-called objective sciences is misplaced, not so much because they (...) are faulty in detail or deficient in humanitarian feel­ing, as because they cannot enjoy the epistemological support that they would require were they allowed the hegemony over other branches of cognition that is traditionally accorded them.” Diefenbeck would not destroy objec­tive knowledge, but would allow each philosophy to confront subjective phi­losophy and from the results of that confrontation build a better system of values. (shrink)

Bastiat emphasized the institutional infrastructure of a market economy and the principle of spontaneous order. He began with first principles — the primacy of property and consent — and derived the legitimate functions of government. As a pioneer in constitutional political economy, he examined the relation between economics and politics, employed methodological individualism, and extended the exchange paradigm to collective choice. He showed that the attenuation of economic liberty in the pursuit of distributive justice under majoritarian government would lead to (...) rent-seeking, corruption, and politicization of economic life.Bastiat met l’accent sur l’aménagement institutionnel de l’économie de marché et sur le principe de l’ordre spontané. Son analyse débute avec les principes premiers — la primauté de la propriété et du consentement — et il infère de ces principes les fonctions légitimes du gouvernement. En tant que pionnier de l’économie politique constitutionnelle, il examine les liens entre la sphère économique et la sphère politique, a recours à l’individualisme méthodologique et étend le paradigme de l’échange aux choix collectifs. Il montre que l’érosion de la liberté économique qu’entraîne la recherche d’une justice distributive sous un gouvernement majoritaire mène à la recherche de rentes, à la corruption et à la politisation de la vie économique. (shrink)

This original and thought-provoking volume examines organic life as subjective activity. It shows that organic life operates differently from objective thought and truth. The volume considers topics such as: the origin of life, the absorption of food, the operation of heredity, and the possible control of further evolutionary development.

In the 16th century Bruno asserted that the earth revolves around the sun. This notion violated the Catholic Church's teaching that the earth was the center of the universe, and his suggestion proved he was a heretic. He was promptly burned at the stake. One hundred years later Galileo said the same thing, and provided evidence. He was forced to recant his views, but he gave the world telescopes so that people could learn for themselves. Today, his assertion is held (...) to be fact with little excitement. Many academics live with a myth of protection; that the pursuit of science, conducted ethically and with methodological rigor, is protected from the slings and arrows of outrageous fortune. Jim Coan's perspective on his experience while an undergraduate student at the University of Washington is important because it sheds light on an unsettling reality; Scientists pursuing unpopular science are no more shielded from attack from scientists and academicians than anyone else. It is particularly worth noting how unpopular science can be attacked in the name of ethics. Although we may be no more enthusiastic about the specific content of the findings than others, ethical academicians and scientists defend unpopular scientific endeavors from attacks leveled on ethical grounds. (shrink)

Despite Plato's various warnings not to do so, his dialogues have been studied as systematic philosophy since antiquity. In this innovative and controversial reassessment, James Arieti argues that they should be read primarily as works of drama rather than philosophical discourse. Analyses of 18 of the 28 dialogues allow the reader to see them as integrated dramas, with all the ambiguities and uncertainties that literary works contain. As in plays generally, the arguments of particular characters cannot be seen as (...) the opinions of the author, whose views emerge only from examining each work as a whole. This literary reading shows how much of the debate about Plato's meaning has been misplaced. Instead of demonstrating that an argument is fallacious or valid, we need to ask why Plato has the particular character make the argument. Interpreting Plato achieves what no other work on Plato has attempted: to see the philosophical arguments as serving a dramatic purpose. (shrink)

This paper traces the development of a deliberate and intense emphasis on visuality in literary representation of the second through fourth centuries C.E., resulting in a new cultural phenomenon: attributing the characteristics and functions of images to living persons. Calling on a range of sources from Lucian's Eikones to the Life of St. Daniel the Stylite and recent scholarship in art history and critical theory, the paper analyzes a series of interfaces between verbal and visual representation in terms of an (...) active transaction between viewer and viewed to construct meaning and establish and communicate social power. (shrink)

Truth-talk exhibits certain features that render it philosophically suspect and motivate a deflationary account. I offer a new formulation of deflationism that explains truth-talk in terms of semantic pretense. This amounts to a fictionalist account of truth-talk but avoids an error-theoretic interpretation and its resulting incoherence. The pretense analysis fits especially well with deflationism’s central commitment, and it handles truth-talk’s unusual features effectively. In particular, this approach suggests an interesting strategy for dealing with the Liar paradox. This version of deflationism (...) has advantages over the formulations currently available in the literature, mainly because it offers a more satisfying account of the generalizing role deflationary views take as truth-talk’s central function. Explaining the notion of truth in terms of pretense generates some special concerns, but none we cannot address through careful consideration of how pretense operates in truth-talk and of the attitudes instances of pretending involve. (shrink)

In what may be the most radical business book ever published, philosopher Jay Ogilvy shows that living without a goal is the only way to accomplish anything. In the 1980s we ran our lives with all the direction and confidence filofaxes and to-do lists could provide. Always knowing exactly where we were headed, we climbed toward the goals corporate America held out in front of us like so many carrots: higher salaries, better titles, more impressive offices. But after a decade (...) of climbing, the air is getting thin. We crave the chance to create, to express ourselves, and to make a difference, not just a living. It is time, says businessman/philosopher James Ogilvy, to tear up the to-do lists and grant ourselves the freedom to enjoy what E. M. Forster calls "the lights and shades that exist in the greyest conversation." Ogilvy shows that richness and color and flavor flood back into our lives once we set aside the goals that hold us captive. He explores how philosophers (from Plato to Nietzsche), lovers, ideologues, and executives have at one time or another lived without goals. What emerges from his argument is a new look at how to achieve personal creativity and freedom by fashioning one's day to-day life, not as a larger goal-producing machine, but as a personal work of art. (shrink)

How is one to distinguish a true lover of peace from a mere appeaser, a pacifist, and a warmonger? Distinguishing them can be sometimes confusing, as they will often appropriate each other’s language. The criterion for the above distinction does not only lie in outward behavior, as knowledge of inward attitudes is also required. A right understanding of these attitudes and motivations involve at least an implicit grasp of the true nature of peace, which is investigated as something more than (...) the mere absence of war, insofar as peace is primarily a work of two moral virtues: justice and charity. It is in the spirit of justice and charity that the true lover of peace must then distinguish—both in one’s own life and with nations—between what can be ignored and / or forgiven, and what must be redressed. Furthermore, the distinction between the lover of peace and the pacifist, with the possibility of pacifism being a distinct tradition from just war philosophy, is investigated. The argument is made that pacifism should not be considered outside the context of just war because one needs that context to address if and who demands restitution. (shrink)

This paper defends physical becoming against Grünbaum's attack, by constructing three arguments in favor of physical becoming. Of the three, I rely primarily on an argument from the philosophy of language, and especially on the principle that tensed discourse involves presuppositions and commitments that Grünbaum's account of becoming cannot handle. I show that Grünbaum's analysis of becoming can provide only a very implausible reconstruction of the temporal coordination of speakers engaged in discourse.

This essay examines the evolutionary development of the “rights” concept. It argues that the concept is both relatively recent and fundamentally economic rather than abstractly philosophical. The essay is unique, not only in its explication of the concept, but also in the use of ngram data to visualize the correspondence between the evolving rights concept and growing aggregate prosperity.

At one time behavioristic psychology depreciated the value of introspection and descriptive observation in an attempt to exorcise the ghosts of mentalism and introspectionism. The roots of this bias were traced to a Cartesian dualism of subject and object. Behavioristic research has typically concentrated on a specific kind of data requiring the controls of a detached third-person observer. Its findings have been far removed from the concrete "lived world" of the subject, notwithstanding the sophistication and utility of its experimental designs. (...) The task of understanding the human world of everyday life has been precluded from investigation by an exclusive reliance on explanation for the purpose of facilitating prediction. A case has been made that such a position is neither philosophically tenable nor conducive to the growth of psychology as a science. The contention of contemporary philosophers and behavioral scientists is that psychology cannot proceed as an independent science of man without combining empirical induction with experiential descriptions. Psychologists cannot exclude the role of intentionality and remain consistently within the orbit of causality. A science of psychology as the study of behavior and experience is possible through a comprehensive approach with equitable sharing of methodologies. Two methods were presented: The method of Phenomenal Study, and the method of Individual Reflection. Experiences from the real world may be studied without the earlier pitfalls of "introspectionism," or the present outcries against a meaningfulness. An application of the two methods to the experience of "feeling understood," suggests a necessary and possible rapprochement between the methods of behaviorism and phenomenology. (shrink)

This study explores professional footballers’ perceptions of where banter crosses the conceptual line into bullying. The study’s focus is of importance, given the impact that abusive behaviors have been found to have on the welfare and safeguarding of English professional footballers. A phenomenological approach was adopted, which focused on the essence of the participants’ perceptions and experiences. Guided by Interpretative Phenomenological Analysis, individual semi-structured interviews were conducted with 18 male professional footballers from three Premier League and Championship football clubs. The (...) findings from this study revealed several key superordinate themes in relation to the dividing line between bullying and banter. These themes included “perception,” “intentionality,” “detecting the line,” and “having a bit of banter.” The findings demonstrate how perceptions of bullying and banter are nuanced by individual differences among the players and the culture of the professional football context. Specifically, it was found that the professional football context can legitimize forms of humor blurring the lines between bullying and banter, challenging the typically positive view of the concept of banter in this environment. From an applied perspective, these findings highlight the need for coaches, players, and football clubs more broadly to address cultural expectations around banter in their environment, while educating individuals around their own perceptions of bullying and banter. (shrink)